Gene information
Official symbol CD40
Official full name CD40 molecule
Gene type protein-coding gene
Chromosome20q13.12
Alias symbolp50; Bp50
Previous symbolTNFRSF5
Gene familyCD molecules; Tumor necrosis factor receptor superfamily
Resources
Entrez Gene 958
HGNC HGNC:11919
Ensembl ENSG00000101017
Vega OTTHUMG00000033053
UCSC uc002xrg.2
GO terms: 132 records
GO Description Category LogP Number of genes Detail
GO:0001562 response to protozoan GO Biological Processes -4.01585848 7 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0002221 pattern recognition receptor signaling pathway GO Biological Processes -6.97185167 18 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002449 lymphocyte mediated immunity GO Biological Processes -8.72662877 18 More
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -11.9339394 22 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002699 positive regulation of immune effector process GO Biological Processes -18.3926498 29 More
GO:0002700 regulation of production of molecular mediator of immune response GO Biological Processes -19.7615296 26 More
GO:0002702 positive regulation of production of molecular mediator of immune response GO Biological Processes -12.4206918 17 More
GO:0002703 regulation of leukocyte mediated immunity GO Biological Processes -18.0432682 27 More
GO:0002705 positive regulation of leukocyte mediated immunity GO Biological Processes -8.38274670 14 More
GO:0002706 regulation of lymphocyte mediated immunity GO Biological Processes -13.7265777 21 More
GO:0002708 positive regulation of lymphocyte mediated immunity GO Biological Processes -8.31079168 13 More
GO:0002712 regulation of B cell mediated immunity GO Biological Processes -6.15575915 8 More
GO:0002714 positive regulation of B cell mediated immunity GO Biological Processes -6.30679788 7 More
GO:0002764 immune response-regulating signaling pathway GO Biological Processes -3.80325753 14 More
GO:0002819 regulation of adaptive immune response GO Biological Processes -16.0189388 24 More
GO:0002821 positive regulation of adaptive immune response GO Biological Processes -12.1298033 16 More
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -14.6775052 22 More
GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -10.1498702 14 More
GO:0002889 regulation of immunoglobulin mediated immune response GO Biological Processes -6.15575915 8 More
GO:0002891 positive regulation of immunoglobulin mediated immune response GO Biological Processes -6.30679788 7 More
GO:0006873 cellular ion homeostasis GO Biological Processes -10.3574947 26 More
GO:0006874 cellular calcium ion homeostasis GO Biological Processes -8.17100062 15 More
GO:0006875 cellular metal ion homeostasis GO Biological Processes -10.3879696 23 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0009615 response to virus GO Biological Processes -11.2861143 47 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0010594 regulation of endothelial cell migration GO Biological Processes -41.8778170 72 More
GO:0010595 positive regulation of endothelial cell migration GO Biological Processes -28.3201829 45 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010634 positive regulation of epithelial cell migration GO Biological Processes -29.2566722 52 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0019724 B cell mediated immunity GO Biological Processes -7.00231964 14 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0030003 cellular cation homeostasis GO Biological Processes -9.22969208 24 More
GO:0030168 platelet activation GO Biological Processes -17.9354931 20 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030888 regulation of B cell proliferation GO Biological Processes -7.97568198 10 More
GO:0030890 positive regulation of B cell proliferation GO Biological Processes -8.50618951 9 More
GO:0032655 regulation of interleukin-12 production GO Biological Processes -15.9447313 16 More
GO:0032735 positive regulation of interleukin-12 production GO Biological Processes -12.7826256 12 More
GO:0032944 regulation of mononuclear cell proliferation GO Biological Processes -24.6915018 34 More
GO:0032946 positive regulation of mononuclear cell proliferation GO Biological Processes -20.2231223 25 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034341 response to interferon-gamma GO Biological Processes -10.8524889 26 More
GO:0034612 response to tumor necrosis factor GO Biological Processes -24.4651326 32 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042113 B cell activation GO Biological Processes -5.56585733 12 More
GO:0042832 defense response to protozoan GO Biological Processes -4.13020121 7 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043087 regulation of GTPase activity GO Biological Processes -2.19988031 26 More
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO Biological Processes -8.71585030 18 More
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO Biological Processes -8.04470175 15 More
GO:0043235 receptor complex GO Cellular Components -19.4198369 40 More
GO:0043405 regulation of MAP kinase activity GO Biological Processes -18.9267681 42 More
GO:0043406 positive regulation of MAP kinase activity GO Biological Processes -13.8261343 18 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043491 protein kinase B signaling GO Biological Processes -12.2973970 11 More
GO:0043536 positive regulation of blood vessel endothelial cell migration GO Biological Processes -25.0316183 33 More
GO:0043547 positive regulation of GTPase activity GO Biological Processes -1.94334853 20 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0046649 lymphocyte activation GO Biological Processes -10.1732143 26 More
GO:0050670 regulation of lymphocyte proliferation GO Biological Processes -22.6006415 32 More
GO:0050671 positive regulation of lymphocyte proliferation GO Biological Processes -19.1485102 24 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.9747849 34 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050801 ion homeostasis GO Biological Processes -12.0812968 60 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050864 regulation of B cell activation GO Biological Processes -7.98662389 16 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050871 positive regulation of B cell activation GO Biological Processes -8.77049404 15 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051052 regulation of DNA metabolic process GO Biological Processes -4.01973325 42 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0051092 positive regulation of NF-kappaB transcription factor activity GO Biological Processes -14.8614421 21 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051251 positive regulation of lymphocyte activation GO Biological Processes -20.2181987 37 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051607 defense response to virus GO Biological Processes -3.02916189 22 More
GO:0055065 metal ion homeostasis GO Biological Processes -12.9426258 29 More
GO:0055074 calcium ion homeostasis GO Biological Processes -10.3600555 19 More
GO:0055080 cation homeostasis GO Biological Processes -11.5718912 30 More
GO:0055082 cellular chemical homeostasis GO Biological Processes -17.6289728 71 More
GO:0070555 response to interleukin-1 GO Biological Processes -18.9736890 36 More
GO:0070663 regulation of leukocyte proliferation GO Biological Processes -26.8242532 37 More
GO:0070665 positive regulation of leukocyte proliferation GO Biological Processes -21.5362473 27 More
GO:0071214 cellular response to abiotic stimulus GO Biological Processes -11.2775864 23 More
GO:0071260 cellular response to mechanical stimulus GO Biological Processes -11.7214175 13 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071347 cellular response to interleukin-1 GO Biological Processes -16.1002741 19 More
GO:0071356 cellular response to tumor necrosis factor GO Biological Processes -22.5666334 29 More
GO:0071496 cellular response to external stimulus GO Biological Processes -17.0078490 52 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071902 positive regulation of protein serine/threonine kinase activity GO Biological Processes -13.5008002 23 More
GO:0072503 cellular divalent inorganic cation homeostasis GO Biological Processes -7.40235615 16 More
GO:0072507 divalent inorganic cation homeostasis GO Biological Processes -10.6286093 21 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0098771 inorganic ion homeostasis GO Biological Processes -12.1048319 31 More
GO:0098797 plasma membrane protein complex GO Cellular Components -14.6387951 39 More
GO:0104004 cellular response to environmental stimulus GO Biological Processes -11.2775864 23 More
GO:0140546 defense response to symbiont GO Biological Processes -3.00647654 22 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:1904035 regulation of epithelial cell apoptotic process GO Biological Processes -21.2824424 33 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000351 regulation of endothelial cell apoptotic process GO Biological Processes -18.6276983 25 More
KEGG pathways: 9 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa05144 Malaria KEGG Pathway -31.5561809 24 More
hsa05145 Toxoplasmosis KEGG Pathway -13.6215025 17 More
hsa05169 Epstein-Barr virus infection KEGG Pathway -3.79267986 10 More
hsa05320 Autoimmune thyroid disease KEGG Pathway -5.52369866 7 More
hsa05322 Systemic lupus erythematosus KEGG Pathway -4.88971598 10 More
hsa05330 Allograft rejection KEGG Pathway -10.3501019 10 More
hsa05340 Primary immunodeficiency KEGG Pathway -1.87435466 3 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
Drug-Gene interaction
view
Related drugs: 11 records
Drug name Interaction type Source PMID View
apx-005m TTD view
bleselumab TTD view
dacetuzumab inhibitor TdgClinicalTrialChemblInteractions 15087402 view
fludarabine NCI 9450802 view
hydroquinone NCI 17118622 view
iscalimab antibody TTD view
lucatumumab TdgClinicalTrial view
pg-102 inhibitor ChemblInteractions view
ravagalimab TTD view
streptozocin NCI 1501618411937525 view
teneliximab partial agonist ChemblInteractions view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
NG_007279.1:g.[5077T>C;6042T>G] genomics myocardial infarction[diagnosis] myocardial infarction Soussi M et al. Biomarkers. 2019
tumor necrosis factor receptor superfamily member 5 proteomics thrombolytic agent[treatment (pharmacotherapy)] acute ST elevation myocardial infarction Halvorsen S et al. Thromb Res. 2012
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